In this article, we present an assessment of the quality of life in patients with end-stage chronic kidney disease, receiving replacement therapy by hemodialysis. We give definitions of hemodialysis, chronic kidney disease, the mental component of health, and the physical component of health. The aim of this work is to evaluate the quality of life indicators in patients with end-stage chronic kidney disease, undergoing hemodialysis. The objective of the study is to identify the relationship between the quality of life indicators on the one hand and the nutritional status and the duration of hemodialysis on the other. We present the current KDQOL-SF questionnaire tailored for assessing the quality of life indicators in patients with chronic kidney disease. The nutritional status of the patients was assessed using clinical data: the body mass index, the skin and fat folds over triceps, the shoulder muscle circumference, the albumin laboratory values,and the absolute number of lymphocytes in 20 patients with end-stage chronic kidney disease. All of them were receiving treatment in the dialysis department of the Kaliningrad Regional Hospital. In conclusion, we establish the relationship between the quality of life in patients with end-stage chronic kidney disease, receiving hemodialysis, and the duration of treatment by hemodialysis.