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Natural and medical sciences

2023 Issue №3

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Tikhonov S.L. Tikhonova N.V. Ulitina E.A.

Comparative evaluation of the biological effect of native and synthesized peptides

DOI
10.5922/gikbfu-2023-3-8
Pages
106-117
cow colostrum peptides synthesized peptides molecular weight ami­no acid sequence cytotoxicity antihyperglycemic effect antioxidant activity

Abstract

Biologically active peptides are considered as preventive and therapeutic agents for vari­ous diseases. Due to the high cost and complexity of isolating native peptides for use in phar­maceuticals, synthetically produced peptides are increasingly being used in dietary supple­ments. The aim of the research is to confirm the similarity and biological activity of synthe­sized peptides compared to native peptides. Synthesized and native peptides from bovine co­lostrum with the code names T1.1 and mpT2 were used as the objects of the study. The pep­tides were synthesized using the solid-phase method. Peptide T1.1 is similar to the peptide «POSSUM_01-POSSUM-C-EMBRYO-2KB», the biological activity of which has not been studied. Peptide mpT2 is similar to the anti-diabetic peptide «LL-16 Alytes obstetricans». It has been proven that the synthesized peptides do not differ from natural ones in terms of physical and chemical characteristics. Both synthesized and natural peptides are non-toxic. The anti-diabetic effect of natural and synthesized peptide mpT2 on animals with induced type 2 diabetes and the antioxidant activity of synthesized and natural peptide T1.1 have been demonstrated.