Antihyperglycemic effect of peptides of colostrum hydrolysate
- DOI
- 10.5922/vestniknat-2025-3-9
- Pages
- 128-139
Abstract
One of the promising approaches for the prevention and treatment of type 2 diabetes (T2D) is the use of biopeptides derived from proteomics data. The effect of an enzymatic hydrolysate of cow colostrum, containing ten peptides, on the development of type 2 diabetes was studied in male Wistar rats. Three groups of Wistar rats, each consisting of seven animals, were formed for the experiments: Group 1 — intact controls; T2D was induced in rats of Groups 2 and 3. Rats in Group 3 additionally received an intragastric administration of the trypsin hydrolysate of cow colostrum alongside their standard diet. In Wistar rats with induced T2D, the trypsin hydrolysate of cow colostrum demonstrated antihyperglycemic and antioxidant effects. Blood glucose and glycated hemoglobin levels decreased in T2D rats receiving the trypsin hydrolysate compared to untreated T2D rats. Administration of the trypsin hydrolysate to Group 3 rats reduced body weight loss relative to Group 2 and was accompanied by less pronounced hyperglycemia. Levels of malondialdehyde (MDA) and catalase activity decreased, while the levels of reduced glutathione and lipoprotein fractions were normalized.