Characterization and use of synthesized antimicrobial peptide in the composition of biodegradable food film
... materials along with antimicrobial agents. Among the promising prescribed ingredients for biodegradable films are biopeptides with antimicrobial properties. The research goal was to develop a biodegradable food film using a synthesized antimicrobial peptide. The objects of the study were the peptide, test strains of C. albicans, Escherichia coli, and Bacillus subtilis. The confirmation of the purity and primary structure of the peptide was conducted using mass spectrometry. The antimicrobial activity ...
Development and prediction of toxicity of a new antiplatelet food peptide
The development of an antiplatelet peptide was conducted using proteomic databases and the Cybase cyclic peptide database. Toxicity prediction was carried out on the ADMETlab 3.0 platform. The framework used was the cyclic peptide PLP-5, listed under number 1375 in the Cybase database....
Comparative evaluation of the biological effect of native and synthesized peptides
Biologically active peptides are considered as preventive and therapeutic agents for various diseases. Due to the high cost and complexity of isolating native peptides for use in pharmaceuticals, synthetically produced peptides are increasingly being used in dietary ...
Classification and characterisation of a new antimicrobial peptide
... by creating foods with antimicrobial properties, new antimicrobial biologically active additives and medicines.
This study aimed to create, characterise and classify a new AMP. The DRAMP proteomic database was used to design the AMP, and the Peptide Ranker was utilised to predict biological activity (http://distilldeep.ucd.ie/PeptideRanker). The peptide was identified with the help of the EROP-Moscow database (http://erop.inbi.ras.ru/index.html), and its physio-chemical properties were studied ...
Physical and chemical characteristics, antioxidant properties and the effect of the newly synthesized peptide on lipid deposition in cells
A novel peptide, CG-16, with the sequence CHAECGAACKEFCLEG, was designed and synthesized. Studies were conducted to assess its physicochemical properties, antioxidant activity, and effects on lipid deposition in cells in an in vitro experiment. It was established ...
Antihyperglycemic effect of peptides of colostrum hydrolysate
One of the promising approaches for the prevention and treatment of type 2 diabetes (T2D) is the use of biopeptides derived from proteomics data. The effect of an enzymatic hydrolysate of cow colostrum, containing ten peptides, on the development of type 2 diabetes was studied in male Wistar rats. Three groups of Wistar rats, each consisting of seven animals, were formed for the experiments: Group 1 — intact controls; T2D was induced in rats of Groups 2 and 3. ...
