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... imbalance contributes to an increase in the surface expression of late activation molecules (HLA-DR) and apoptosis (CD95), which is necessary to control excessive proliferation of lymphocytes, and, ultimately, prevents the breakdown of immune tolerance mechanisms and the development of hyperproliferative pathologies of the immune system.

Obesity is a global health problem. Non-alcoholic fatty liver disease (NAFLD) in obese patients is 62—93 %, in type 2 diabetes is prevalent and reaches 55.5 %. The development of chronic subclinical inflammation in obesity contributes to the development of oxidative stress and mitochondrial dysfunction, which underlie the pathogenesis of obesity-associated diseases, i. e., type 2 diabetes and NAFLD. The study included 130 patients with morbid obesity and comorbid diseases (NAFLD and type 2 diabetes)...

... potential of a woman, adverse life events, and in adolescent girls it is also a long-term stress which is linked to academic activities. These factors pose a significant threat to mental health, can cause difficulties in adaptation, can become a trigger mechanism for psychopathologies, and also affect the dis­orders, exacerbating the female problems.

... inno­vative development and metabolism processes of explicit and tacit knowledge. Theoretical positions and hypotheses are tested through analyzing official re­gional statistics, as well as the data of the expert survey. The study revealed the intra-system mechanisms to compensate for the reduction of codified knowledge flows in the Rostov agglomeration via the active clustering of in­novation sector, accompanied by the dynamics of tacit knowledge and the shrinking of its spatial imbalances. Moreover, ...

... histopathology // Skin Res. Technol. 2013. Vol. 19, № 1. P. 132—138. 19. Chajra H., Auriol D., Joly F., Pagnon A. Reactivating the extracellular matrix syn­thesis of sulfated glycosaminoglycans and proteoglycans to improve the human skin aspect and its mechanical properties // Clin. Cosmet. Investig. Dermatol. 2016. № 9. P. 461—472. 20. Lee K. W., Kim S. H., Gil Y. C. et al. Validity and reliability of a structured-light 3D scanner and an ultrasound imagingsystem for measurements of facial skin ...

... Дискуссионные вопросы концепции «обучающегося региона» // Вестник Томского государственного университета. 2014. № 387. С. 69—74. 10. Albert R., Barabasi A. L. Statistical Mechanics of Complex Networks // Re­views of Modern Physics. 2002. № 74 (1). P. 47—97. 11. Aroca P., Azzoni C., Sarrias M. Regional concentration and national economic growth in Brazil and Chile // Letters in Spatial and Resource Sciences. 2018. ...

... of the structural features of the Quaternary strata of the Kaliningrad Region. Known for a century and a half and characterized by a variety of forms, they have not yet been practically studied, and there is very little knowledge of their formation mechanisms. Meanwhile, some of the disloca­tions, such as the glacial blocks, may be of interest as amber deposits. The aim of the work is to characterize and systematize the unique glaciotectonic for­mations observed in the surface, mainly Quaternary,...

... with high plowing. Wind erosion of the soil cover is most visible in the northern regions of Chechnya and Dagestan within the Tersko- Kum semi-desert and partly in the Tersko-Sulak lowland. The deflation processes are mainly seen in the soils of light mechanical composition and areas with a diluted grass stand. Degumation of soils varies in all areas, but is most pronounced in cropping areas. The problem of soil salinization is characteristic of arid irrigated areas. In the most developed and densely ...

... domain heart rate variability and heart rate: relations to age and gender over nine decades // J. Am. Coll. Cardiol. 1998. Vol. 31 (3). P. 593—601. 17. Holzman J.B., Bridgett D.J. Heart rate variability indices as bio-markers of topdown self-regulatory mechanisms: a meta-analytic review // Neurosci Biobehav. Rev. 2017. Vol. 74 (Pt A). P. 233—255. 18. Cole R. D., Kawasumi Y., Parikh V. Corticotropin Releasing Factor Impairs Sustained Attention in Male and Female Rats // Behav. Brain Res. 2016. Vol....

... morphological characterization of hemozoin produced by Schistosoma mansoni and Rhodnius prolixus // Febs letters. 2005. Vol. 579, № 27. P. 6010—6016. 5. Sun J., Li C., Wang S. Organism-like formation of Schistosoma hemozoin and its function suggest a mechanism for anti-malarial action of artemisinin // Scientific reports. 2016. Vol. 6. 6. Lamikanra A. A. et al. Hemozoin (malarial pigment) directly promotes apoptosis of erythroid precursors // PloS one. 2009. Vol. 4, № 12. P. e8446. 7. Deroost K....

... planning. The article studies the issues of spatial, territorial and strategic planning in the modern management practice in Russia and in the region of Kaliningrad / Vistula Lagoon in particular. The research focuses on the opportunities of creating mechanisms for coordination and joint work of Russian and Polish partners to provide for common or related programs of spatial planning in the region. The research was carried out by Russian and Polish partners in the framework of the international project ...

... лечении гнойного холангита // Анналы хирургической гепатологии. 2009. Т. 14, № 2. С. 16—21. 6. Binmoeller K. F., Brückner M., Thonke F., Soehendra N. Treatment of difficult bile duct stones using mechanical, electrohydraulic and extracorporeal shock wave lithotripsy // Endoscopy. 1993. N 25. Р. 201—206. 7. Freitas M. L., Bell R. L., Duffy A. J. Choledocholithiasis: evolving standards for diagnosis and management // World J. Gastroenterol. 2006....

... fishing industry and the infrastructural development of the seaport of Kaliningrad. The author attempts to assess the current potential of the regional port infrastructure and the fishing industry of the region as well as highlights the most important mechanisms for the further development of the port as a part of industrial port complex. 1. Булгаков А. А. Критерии оценки эффективности работы морского порта в структуре транспортного ...

... interannual changes in the parameters of mesoscale water dynamics in the upper 200 m layer of the ocean due to the biomass and biological resources distribution, as well as the specific dynamics of the atmospheric processes. The authors identify the scope and mechanisms of the impact of oceanological conditions on the biomass and distribution of commercial horse mackerel concentrations in the southern part of the Pacific Ocean and the Antarctic krill in the Antarctic part of the Atlantic. The possibilities ...

... and hydrogen absorption by steel were compared with the data of quantum chemical computations performed for isolated molecules of the studied inhibitors with the help of the MNDO method. The results obtained point to a difference in the protective mechanisms of the studies inhibitors in case of anticorrosion action and hydrogen absorption by steel. 1. Розенфельд И. Л. Ингибиторы коррозии. М., 1977. 2. Антропов Л. И., Макушин Е. М., Панасенко ...

This article considers the influence of terrain on the assessment of natural system sensitivity to anthropogenic impact. The author presents a classification model of natural system sensitivity to anthropogenic chemical and mechanical impacts. The article examines certain cases of the influence of terrain on the assessment of natural complex sensitivity in the areas of oil exploration drilling located in different geomorphic regions of the Kaliningrad region. 1. Дмитриев ...

... are considered as an integral continuous environment. At the water-air surface, the density changes abruptly from ρ = ρwater = 1000 kg/m3 for water to ρ = ρair = 1.2 kg/m3 for air. The solution to model equations is generalised. The mathematical mechanism of equation solving suggests automatic smoothing of density in the area of wave breaking and formation of a thin fluid layer with an intermediate density. 1. Пелиновский Е. Н. Гидродинамика волн цунами. ...

Experimental research helps explain the mechanism of formation of water reserves in the soils of desert phytocenoses. The author arrives at a conclusion about the development of seasonal heat reactor in deserts, which affects the processes of night water condensation in soils in summer. 1....

This article presents the results of research on the dynamics of cardiovascular system adaptation mechanisms in primary school pupils according to the indices of vegetative and myocardial of haemodynamic homeostasis. 1. Безруких М. М., Сонькин В. Д., Фарбер Д. А. Возрастная физиология. М., 2007. 2....

A series extraction of platinum metals (Pd and Rh) from natural sedimentary samples near the trunk-roads of Rhine-Westphalia was conducted. The authors make an assumption about the mechanism of influence of environmental conditions on the mobility of elements studied. 1. Claus T., Zereini F., Urban H. Verteilung und Konzetrationen von Platin, Palladium und Rhodium in Umweltmaterialien an der Bundesautobahn A5 (Akm 458-Akm 524) ...

The article reviews the research on the influence of abiotic factors on plant antioxidant pool formation conducted at IKSUR. 1. Чиркова Т.   В. Физиологические основы устойчивости растений. СПб., 2002. 2. Тодоров И.   Н., Тодоров Г.   Н. Стресс, старение и их биохимическая коррек­ция. М., 2003. 3. Полесская О.   Г . Растительная клетка и активные формы кислорода. М., 2007. 4. Чупахина Г .   Н. Система аскорбиновой кислоты растений. Калининград, 1997. 5. Зубкова С.   К . и др. Действие...

The specific features of mammals' behaviour in response to external information is determined by innate mechanisms and experience acquired through ontogenesis. The author genetically defines the unstable boundaries of behavioural responses and offers a methodology of research on quantitative animal-habitat interaction. The article emphasises the variability ...

... deterioration and degradation of synthetic polymeric materials: recent research advances // International biodeterioration & biodegrada­tion. 2003. №   52 (2). P. 69−91. 6. Gu J.-D. Microbial colonization of polymeric materials for space applications and mechanisms of biodeterioration // International biodeterioration & biodegrada­tion. 2007. №   59 (3). P. 170−179. 7. Герасименко А.   А. Микромицетная коррозия металлов. Идентификация, культивирование ...

... and degradation of synthetic polymeric materials: recent research advances // International biodeterioration & biodegrada­tion. 2003. №   52 (2). P. 69 − 91. 7. Gu J.-D. Microbial colonization of polymeric materials for space applications and mechanisms of biodeterioration // International biodeterioration & biodegrada­tion. 2007. №   59 (3). P . 170 − 179. 8 . Практикум по микробиологии: учеб. пособие для вузов / под ред. А.   И....

This article focuses on the features of corrosion in Cd-coated st.3 steel in the presence of mycelium minces. The authors show the biocide and inhibitory role of certain N- and O- containing organic compounds in the process of mycelium corrosion and hydrogen absorption of Cd-coated steel. 1.      Iverson W.   P. Biological corrosion // Adv. Corros. Sci. And Technol. 1972. Vol. 2. P. 1—42. 2.      Каневская И.   Г. Биологическое повреждение промышленных материалов. Л., 1984. 3.      ...