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Trulioff A. S. Kutukova N. A. Kudriavtsev I. V.

The role of Fcγ-receptors in the biological action of C-reactive protein on human mast cells

DOI
10.5922/ATB-2026-2-1-2
Pages
17-45
To cite
Trulioff A. S., Kutukova N. A., Kudriavtsev I. V. The role of Fcγ-receptors in the biological action of C-reactive protein on human mast cells. Advanced Targets in Biomedicine. 2026;2(1):17–45.
mast cells inflammation C-reactive protein Fcγ-re­ceptors

Abstract

Current evidence convincingly supports the key role of mast cells in triggering pro-inflammatory reactions, and of fibroblasts in tissue regeneration during the resolution phase of inflammation. Nevertheless, questions concerning their synergy during the acute phase of the inflammatory response — including the influence of acute-phase proteins on intercellular communication — remain poorly studied. In this work, using flow cytometry and quantitative fluorescence-based assessment of cell adhesion, we demonstrate that stimulation of Fcγ receptors on HMC-1 mast cells with specific ligands (C-reactive protein, aggregated immunoglo­bulin G, and serum amyloid P component) enhances the adhesive properties of these cells toward stromal elements — fibroblasts and the extracellular matrix. Notably, native HMC-1 mast cells did not show a secretory response to C-reactive protein sti­mulation in the form of histamine release. The ability to trigger a degranulation response with histamine release upon contact with C-reactive protein was associated with the expression of high-affinity FcγRI receptors, induced on the mast cell membrane by IFNγ. These findings reveal new aspects of the regulation of intercellular inte­ractions under conditions of acute inflammation, highlighting the role of cytokine modulation in the effector functions of immunocompetent cells.

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