Воспалительный синдром восстановления иммунитета у ВИЧ-инфицированных пациентов: факторы риска, клинические проявления, исходы, профилактика
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Аннотация
Установлено, что снижение высокой частоты (62,5 %) неблагоприятных исходов тяжелых форм воспалительного синдрома восстановления иммунитета может быть достигнуто проведением адекватногомониторинга ВИЧ-инфицированных пациентов, заключающегося в ран-нем выявлении, лечении и профилактике коинфекций и своевременномустранении других возможных факторов риска.
This article claims that a decrease in the high frequency (62,5 %) of unfavourable outcomes of severe immune reconstitution inflammatory syndrome can be achieved through an adequate monitoring of HIV-infected patients consisting in early detection, treatment and prevention of coinfections and swift elimination of other risk factors.
Список литературы
1. David M., Willem D. F., Annelies V., Charles F. Immune reconstitution inflammatory syndrome (IRIS): review of common infectious manifestations and treatment options // AIDS Research and Therapy. 2007. P. 4—9. URL: www. aidsrestherapy. com/сontent/4/1/9 (дата обращения: 21.12.2011).
2. Shelburne S. A., Visnegarwalaa F., Darcourtc J. et al. Incidence and risk factors for immune reconstitution inflammatory syndrome during highly active antiretroviral therapy // AIDS. 2005. Vol. 19, № 4. P. 399—406.
3. Breton G., Duval X., Estellat C. et al. Determinants of Immune Reconstitution Inflammatory Syndrome in HIV Type 1—Infected Patients with Tuberculosis after Initiation of Antiretroviral Therapy // Clinical Infectious Diseases. 2004. № 39.P. 1709—1712.
4. Jevtović D. J., Salemović D., Ranin J. et al. The prevalence and risk of immune restoration disease in HIV-infected patients treated with highly active antiretroviral therapy // 2005 British HIV Association HIV Medicine. 2005. № 6. P. 140—143.
5. Cepeda L., Salobreña A., Ortega K. et al. Oral lesions and immune reconstitution syndrome in HIV+/AIDS patients receiving highly active antiretroviral therapy.Epidemiological evidence // Med Oral Patol Oral Cir Bucal. 2008. № 13(2). P. 85—93.
6. Bucy R. P., Hockett R. D., Derdeyn C. A. et al. Pat Initial increase in blood CD4+lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissues // J. Clin. Invest. 1999. № 103. P. 1391—1398.
7. Shelburne S. A., Montes M., Hamil R. J. Immune reconstitution inflammatory syndrome: more answers, more questions // Journal of Antimicrobial Chemotherapy. 2006. № 57. P. 167—170.
8. Beishuizen S. J., Geerlings S. E. Immune reconstitution inflammatory syndrome: immunopathogenesis, risk factors,diagnosis, treatment and prevention // The Netherland Jornal of medicine. 2009. Vol. 67, № 10. P. 327—331.
9. Guidelines for Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents Recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America // Morbidity and Mortality Weekly Report. 2009. Vol. 58, № RR-4. URL: www.cdc.gov/mmwr (дата обращения: 21.12.2011).
10. Барлет Д., Галант Д., Фам П. Клинические аспекты ВИЧ-инфекции. М., 2010.
11. Grant P. M., Komarow L., Andersen J. et al. Risk Factor Analyses for Immune Reconstitution Inflammatory Syndrome in a Randomized Study of Early vs. Deferred ART during an Opportunistic Infection // PLoS ONE. 2010. Vol. 5. URL: www.
plosone.org (дата обращения 21.12.2011).
12. Bonham S., Meya D. B., Bohjanen P. R., Boulware D. R. Biomarkers of HIV Immune Reconstitution Inflammatory Syndrome // Biomark. Med. 2008. № 2(4). P. 349—361.
13. Breton G., Adle-Biassette H., Therby A. et al. Immune reconstitution inflammatory syndrome in HIV-infected patients with disseminated histoplasmosis // AIDS.2006. № 20. P. 119—132.
14. French M. A., Price P., Stone S. F. Immune restoration disease after antiretroviral therapy // AIDS. 2004. № 18. P. 1615—1627.