Case study: treatment of a patient with Т- cell lymphoma (delta-gamma-variant)
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Abstract
In this article, we present a clinical case of a patient with T-cell lymphoma (delta-gamma variant) complicated by neuroleukemia. We performed a differential diagnosis from other lymphoproliferative diseases. Our diagnosis was based on trepanobiopsy and immunophenotyping data: delta-gamma-T/NK-cell lymphoma, hepatolienal form. The first NHL-BFM 90 protocol block was obtained. We performed a whole body PET/CT scan and a myelogram to confirm the diagnosis. Since therapy was ineffective, we conducted two courses of second-line therapy (R-ICE) and received a partial response. Further, allogeneic hematopoietic stem cell transplantation was recommended. After two R-ICE courses, the patient received supportive polychemotherapy (Rituximab + + Gemzar), without progression. Six months later, the patient's condition worsened. We performed spinal puncture and diagnosed neuroleukemia. It was recommended that the patient received a specific course of polychemotherapy. Therefore, patients diagnosed with hepatolienal T-cell lymphoma, in view of the highly aggressive disease course, are recommended to undergo allogeneic transplantation of hematopoietic stem cells as early as possible.
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