IKBFU's Vestnik

2019 Issue №1

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Synthesis of some nitrogen-containing heterocycles based on benzotriazole and bromo-substituted and condensed quinones



In this article, we describe the process of obtaining nitrogen-containing heterocycles based on benzotriazole and bromo-substituted and condensed quinones. As known, nitrogen-containing heterocyclic compounds containing amide function are used in the synthesis of biologically active substances. One can expect products synthesized with quinones and heterocyclic amines of the benzotriazole series to have a wide spectrum of biological activity and other useful properties.


1. Monbaliu J.-C. M. The Chemistry of Benzotriazole Derivatives: A Tribute to Alan Roy Katritzky. Switzerland, 2016.

2. Панкратов А. Н. Методология простой квантовохимической оценки твер­дофазных теплот образования при постоянстве межмолекулярных взаимодей­ствий в рядах соединений (на примере хинонов) // Журнал структурной хи­мии. 2007. Т. 48, № 3. С. 478—484.

3. Kashiwagi K., Tanaka I., Tamura M. et al. Anthraquinone Polyamines: Novel Channel Blockers to Study N-Methyl-D-Aspartate Receptors // Journal of Pharma­cology and Experimental Therapeutics. 2004. Vol. 309, № 3. Р. 884—893.

4. Loddo R., Novelli F., Sparatore A. Anriviral activity of benzotriazole derivaties. 5-[4-(Benzotriazol-2-yl)phenoxy]-2,2-dimethylpentanoic acids potently and selective­ly inhibit Coxsackie Virus B5 // Bioorganic & Medicinal Chemistry. 2015. Vol. 23, № 21. P. 7024—7034.

5. Jamkhandi C. M., Disouza J. I., Asgekar S. D. et al. Synthesis, in vitro anti-inflam­matory activity and qsar evaluation of benzotriazolyl-3-(2-hydroxyphenyl)prop-2-enoic acid derivatives // European Journal of Pharmaceutical and Medical Research. 2015. Vol. 2, № 5. Р. 799—810.