IKBFU's Vestnik

2012 Issue №07

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The state of antioxidant system in patients with alcohol abuse

Pages
28-32

Abstract

A study into the content water-soluble antioxidants, ceruloplasmin and iron (III) in the blood serum in patients with alcohol abuse showed significant changes to the antioxidant system: an increase in the content of antioxidants and ceruloplasmin decreased and a decrease in that of iron (III). The authors focus on the gender-related differences: men exhibit greater changes in the content of antioxidants, whereas women in that of ceruloplasmin and iron (III).

Reference

1. Halliwell B. Biochemistry of oxidative stress // Biochemistry Society transactions.2007. Vol. 35. P. 1147—1150.
2. Duračková Z. Some current insights into oxidative stress // Physiol. Res. 2010.Vol. 59. P. 459—469.
3. Uhlikova E., Kupcova V., Szantova M. Plasma copper and ceruloplasmin in patients with alcoholic liver steatosis // Bratisl. Lek. Listy. 2008. Vol. 109. P. 431—433.

4. Nordmann R. Alcohol and antioxidant systems // Alcohol. Alcohol. 1994. Vol. 29.P. 513—522.
5. El.-Sokkary G., Reiter R. J., Tan D.-X. et al. Inhibitory effect of melatonin on products of lipid peroxidation resulting from chronic ethanol administration // Alcohol & Alcoholism. 1999. Vol. 34. № 6. P. 842—850.
6. Kusano C., Ferrari B. Total antioxidant capacity: a biomarker in biomedical and nutritional studies // Journal of cell and molecular biology. 2008. Vol. 7. P. 1—15.
7. Мисин В. М., Сажина Н. Н., Короткова Е. И. Сравнительный анализ суммарного содержания антиоксидантов и их активности в плазме крови человека //Тезисы докладов VIII Международной конференции «Биоантиоксидант». М.,2010. С. 303—304.
8. Sies H. Total antioxidant capacity: appraisal of a concept // Theу journal of
nutrition. 2007. Vol. 137. P. 1493—1495.
9. Pavk Y. S., Suzuki K., Mumby S. et al. Antioxidant binding of caeruloplazmin to myeloperoxidase: myeloperoxidase is inhibited, bur oxidase, peroxidise and immunoreactive properties of caeruloplazmin remain intact // Free Rad. Res. 2000. Vol. 33.P. 261—265.
10. Ващенко В. И., Ващенко Т. Н. Церулоплазмин — от метаболита до лекарственного средства // Психофармакология и биологическая наркология. 2006. Т. 6.С. 1254—1269.
11. Hamed S. A., Abdellah M. M., El-Melegy N. Blood levels of trace elements, electrolytes, and oxidative stress/antioxidant systems in epileptic patients // J. Pharmacol.Sci. 2004. Vol. 96. P. 465—473.
12. Yashin Ya. I., Nemzer B. V., Ryzhnev V. Yu. et al. Creation of a Databank for Content of Antioxidants in Food Products by an Amperometric Method // Molecules.2010. Vol. 15. P. 7450—7466.
13. Noyer M., Dwulet F. E., Hao Y. L., Putnam F. W. Purification and characterization of undegraded human ceruloplasmin // Anal. Biochem. 1980. Vol. 102. P. 450—458.
14. Upadhyaya Ch., Mishra S., Ajmera P., Sharma P. Serum iron, copper and zinc status in maternal and cord blood // Indian Journal of Clinical Biochemistry. 2004.Vol. 19. P. 48—52.