Evaluation of acute contact toxicity of imidacloprid and thiacloprid to honey bees: A comparative analysis of effects on survival and behavioral activity
The paper presents the results of a study of the acute contact toxicity of imidacloprid and thiacloprid to honey bees (Apis mellifera Linnaeus, 1758). The experiment assessed survival and behavioral activity of insects at 4, 24, and 48 hours after a single exposure to various concentrations of the insecticides. It ...
Comparative evaluation of the biological effect of native and synthesized peptides
Biologically active peptides are considered as preventive and therapeutic agents for various diseases. Due to the high cost and complexity of isolating native peptides for use in pharmaceuticals, synthetically produced peptides are increasingly being used in dietary supplements. The aim of the research is to confirm the similarity and biological activity of synthesized peptides compared to native peptides. Synthesized and native peptides from bovine colostrum with the code names T1.1 and mpT2...
Development and prediction of toxicity of a new antiplatelet food peptide
The development of an antiplatelet peptide was conducted using proteomic databases and the Cybase cyclic peptide database. Toxicity prediction was carried out on the ADMETlab 3.0 platform. The framework used was the cyclic peptide PLP-5, listed under number 1375 in the Cybase database. A new peptide with the amino acid sequence QLSNGLFVDYLWW was obtained. According to the ...
Perspectives of using of composite nano- and micromaterials as agents for biomedical applications
... (nanostars) and micromaterials (microdisks) against Jurkat, Huh7 cell cultures, and human mononuclear cells in in vitro conditions. A concentration-dependent cytotoxic effect of nanoparticles was observed. At the same time, microdisks did not exhibit any toxic effects on the studied cells. The potential of using nano- and micromaterials as prospective tools for cancer therapy, specifically for photothermal therapy, was also discussed.
nanoparticles, microdiscs, photothermal therapy, cytotoxicity,...
