Cytokine-induced regulation of maturation, differentiation, and apoptotic death of immune memory T-lymphocytes
... normal functioning of the immune system by maintaining the balance of homeostatic proliferation and apoptotic death. We also noted that cytokine imbalance contributes to an increase in the surface expression of late activation molecules (HLA-DR) and apoptosis (CD95), which is necessary to control excessive proliferation of lymphocytes, and, ultimately, prevents the breakdown of immune tolerance mechanisms and the development of hyperproliferative pathologies of the immune system.
Yurova K.A., ...
