NONE20260602013649747Immanuel Kant Baltic Federal Universityno-reply@journals.kantiana.ruImmanuel Kant Baltic Federal UniversityIKBFU's Vestnik. Series: Natural Sciences2500-32080602202611R.BogachevThe author uses the notion of residual risk for the assessment of myocardial infarction (MI). In the acute phase of myocardial infarction, the majority of patients have remodelling of the myocardium with a predominant combination of cavity dilatation and hypertrophic left ventricle. One third of patients having endothelial dysfunction have remodelling of the myocardium. It explains a greater frequency of angina pectoris and the development of heart failure symptoms. Persistent remodelling is associated with impaired endothelium-dependent vasodilation; a significant number of patients develop paradoxical vasoconstriction. A combination of these factors largely determines the degree of residual risk after myocardial infarction. In addition to standard therapy, post-MI therapy should be aimed at correcting the remodelling of blood vessels and the myocardium. It will prevent the development of delayed complications.06022026111. Mendis S., Thygesen K., Kuulasmaa K. et al. World Health Organization definition of myocardial infarction: 2008—09 revisio // International Journal of Epidemiology. 2011. Vol. 40. Р. 139—146.2. Thygesen K., Alpert J. S., White H. D. Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. Universal definition of myocardial infarction // Circulation. 2007. Vol. 116. P. 2634—2653.3. Rodriguez-Granillo G. A. Long-term effect of perindopril on coronariaterosclerosis progression (from the perindopril/ s Prospective Effect on Coronariaterosclerosis bу Angiographу and Intravascular Ultrasound Evaluation [PERSPECTIVE] // The American Journal of Cardiology. 2007. Vol. 100. P. 159—163.4. Трухан Д. И., Тарасова Л. В. Оптимизация лекарственной терапии ишемической болезни сердца и артериальной гипертензии: выбор ингибитора ангиотензинпревращающего фермента // Системные гипертензии. 2014. Т. 11, № 1. С. 73—77.5. Чернявская Т. К. Современные подходы к диагностике и коррекции эндотелиальной дисфункции у пациентов с артериальной гипертонией // Лечебное дело. 2013. № 2. С. 118—130.A.PashovE.SivovaA.KirichenkoThe authors evaluated the effectiveness of a complex conservative therapy in childless women of reproductive age having atypical endometrial hyperplasia and well-differentiated endometrial carcinoma. The study examines the effectiveness of combining the gonadotropin-releasing hormone agonist (GnRH) and the levonorgestrel-releasing intrauterine system. All patients had immunohistochemical staining for ER, PR, ki-67, bcl-2, p 53, E-cadherin before and after treatment. From 2008 to 2015, none of the patients had a progression of the disease; all patients have exceeded the five year survival rate. 15 patients (30 %) had spontaneous pregnancy. A combination of GnRH and LNG-IUD proved to be highly efficient for treating atypical endometrial hyperplasia (AEH) and EC-G1.06022026111. Аксель Е. М. Заболеваемость и смертность от злокачественных новообразований органов женской репродуктивной системы в России // Онкогинекология. 2015. № 1. С. 6—15.2. Бохман Я. В. Руководство по онкогинекологии. СПб., 2002.3. Лысенко О. В. Классификация и гормональная терапия гиперпластических процессов эндометрия // Охрана материнства и детства. 2008. № 2. С. 100—115.4. Способ лечения начального рака эндометрия : пат. № 2428201 Рос. Федерация. № 2010131735/15 ; опубл. 10.09.2011, Бюл. № 25.5. Пашов А. И., Цхай В. Б., Дыхно Ю. А. Пролиферативные процессы эндометрия: патогенез, прогнозирование, ранняя диагностика. Новосибирск, 2013.6. Новикова Е. Г., Чулкова О. В., Пронин С. М. Предрак и начальный рак эндометрия у женщин репродуктивного возраста. М., 2005.7. Новикова О. В., Новикова Е. Г., Лозовая Ю. А. и др. Самостоятельная гормонотерапия как альтернатива хирургическому лечению предрака и начального рака эндометрия у пациенток репродуктивного возраста // Онкогинекология. 2015. № 3. С. 25—33.8. Чернышова А. Л., Коломиец Л. А., Бочкарева Н. В. Иммуногистохимические критерии прогноза при раке эндометрия // Сибирский онкологический журнал. 2010. № 37. С. 79—84.9. Шахламова М. Н., Исаева Э. А., Панкратов В. В. Этиология и патогенез гиперпластических процессов эндометрия в постменопаузе // Вопросы гинекологии, акушерства и перинатологии. 2011. Т. 10, № 4. С. 76—84.10. Шешукова Н. А., Макаров О. И., Фомина М. Н. Гиперпластические процессы эндометрия: этиопатогенез, клиника, диагностика, лечение // Акушерство и гинекология. 2011. № 4. С. 16—21.11. Ahmed R. H. Ahmed, Eman M. S. Muhammad. E-cadherin and CD10 expression in atypical hyperplastic and malignant endometrial lesions // J. Egypt Nation. Can. Inst. 2014. Vol. 26, № 4. P. 211—217.12. Carico E., Atlante M., Giarhieri E., Raffa S. E-Cadherin and Alpha-Catenin Expression in Normal, Hyperplastic and Neoplastic Endometrium // Antican Research. 2010. Vol. 30, № 12. P. 4993—4997.13. Craig A. M., Hou J. Y., Goldberg G. L., Kuo D. Y. S. Angiogenesis and its modulation in the pathophysiology and treatment of endometrial carcinoma // Oncol. Rev. 2011. Vol. 5. P. 43—48.14. Epplein M., Reed S. D., Voigt L. F. et al. Risk of complex and atypical hyperplasia in relation to anthropometric measures and reproductive history // Am. J. Epidemiol. 2008. Vol. 168, № 6. P. 563—570.15. Liang Y. L., Hao Q., Zhang H.-M. et al. Insulin-like growth factors in endometrioid adenocarcinoma: Correlation with clinico-pathological features and estrogen receptor expression // BMC Cancer. 2012. Vol. 12, № 1. P. 262—273.16. Lie D. I., Georgescu C. V., Simionescu C. et al. Immunohistochemical aspects of endometrium hyperplasia in perimenopause // Cur. Heal. Scien. J. 2011. Vol. 37, № 2. P. 85—91.17. Haola Z. J., Walker K. F., Powell M. C. Levonorgestrel intra-uterina system as a treatment option for complex endometrial hyperplasia // Eur. J. Obstet. Gynecol. Reprod. Biol. 2011. Vol. 159, № 1. P. 176—179.18. Linkov F., Edwards R., Balk J. et al. Endometrial hyperplasia, endometrial cancer and prevention: gaps in existing research of modifiable risk factors // Eur. J. Cancer. 2008. Vol. 44, № 12. P. 1632—1644.19. Pashov A. I., Tshay V. B., Ionouchene S. V. The combined GnRH-agonist and intrauterine levonorgestrel-releasing system treatment of complicated atypical hyperplasia and endometrial cancer: a pilot study // Gynecol. Endocrinol. 2012. № 2. P. 559—561.20. Pronin S. M., Novikova O. V., Novikova E. G., Andreeva J. Y. Fertility-sparing treatment of early endometrial cancer and complex atypical hyperplasia in young women of childbearing potential // International Journal of Gynecological Cancer. 2015. Т. 25, № 6. С. 1010—1014.21. Qvigstad E., Lieng M. Surgical Treatment of Endometrial Cancer and Atypical Hyperplasia: A Trend Shift from Laparotomy to Laparoscopy // Obstet. Gynecol. Int. 2011. Vol. 2011, № 5. P. 1—5.22. Rodriguez F. J., Lewis-Tuffin L. J., Anastasiadis P. Z. E-cadherin's dark side: Possible role in tumor progression// Bioch. Bioph. Acta. Rev. Can. 2012. Vol. 1826, № 1. P. 23—31.23. Sorosky J. I. Endometrial cancer // Obstet. Gynecol. 2012. Vol. 120, № 2 (P. 1). P. 383—397.24. Trimble C. L., Method M., Leitao M. et al. Management of Endometrial Precancers // Obst. Gync. 2012. Vol. 120, № 5. P. 1160—1175.25. Van Roy F. Beyond E-cadherin: roles of other cadherin superfamily members in cancer // Nat. Rev. Can. 2014. Vol. 14. P. 121—134.26. Van Roy F., Berx G. The cell-cell adhesion molecule E-cadherin // Cell. Mol. Life Sci. 2008. Vol. 65, № 23. P. 3756—3788.27. Varma R. The effectiveness of a levonorgestrel-releasing intrauterine system (LNG-IUS) in the treatment of endometrial hyperplasia — a long-term follow-up study // Eur. J. Obstet. Gynecol. Reprodact. Biology. 2008. Vol. 139. P. 169—175.28. Viola A. S., Gouveia D., Andrade L. Prevalence of endometrial cancer and hyperplasia in non-symptomatic overweight and obese women // Aust. N. Z. J. Obstet. Gynaecol. 2008. Vol. 48, № 2. P. 207—213.29. Wang S., Wang Z., Mittal K. Concurrent endometrial intraepithelial carcinoma (EIC) and endometrial hyperplasia // Hum. Pathol. 2015. Vol. 2, № 1. P. 1—4.I.BarsukovThe author studies pain relief effect of flupirtine in patients with diabetic polyneuritis. In the conducted study, 112 patients were treated with flupirtine: 102 (91.1 %) men and 9 (8.9 %) women. All patients had diabetes with clinical manifestations of sensorimotor polyneuropathy accompanied by pain. The author proves that flupirtine can be successfully used for pain relief as part of a complex therapy in both inpatient and outpatient departments.06022026111. Левин О. С. Полиневропатии : клиническое руководство. М., 2006.2. Жулев Н. М., Осетров Б. А., Жулев С. Н. Невропатии. СПб., 2005.3. Чернышова Т. Е., Гурьева И. В., Алтунбаева Р. А. и др. Диабетическая нейропатия (патогенез, диагностика, лечение). М., 2005.4. Баринов А. Н., Строков И. А., Яхно Н. Н. Клинические проявления болевого синдрома при дистальной диабетической полиневропатии // Боль. 2003. № 1. С. 21—25.5. Рачин А. П. Десять доказательств успешного применения флупиртина (катадолона) при болях в нижней части спины // Лечение нервных болезней. 2007. Т. 8, № 2. С. 35—39.6. Besson J. M. The neurobiology of pain// Lancet. 1999. Vol. 353. P. 1610—1615.7. Chung J. W., Wong M. C., Wong T. K. Effects of treatments for symptoms of painful diabetic neuropathy // Systematic review. 2007. Vol. 335. P. 87—91.8. EMA Restrictions in the use of flupirtine-containing medicines — CMDh endorses PRAC recommendation. 28.06.2013 EMA/384191/2013.9. EMA — Science, medicines, health PRAC recommends restricting the use of flupirtine-containing medicines. 14.06.2013 EMA/362055/2013.10. Mueller-Schwefe G. Flupirtine in Acute and Chronic Pain Associated with Muscle Tenseness. Results of a Postmarketing Surveillance Study // Fortschr. Med. 2003. Vol. 121. P. 3—10.11. Rationale for the triggering of procedure under Article 107i of Directive 2001/83/EC on flupirtine presented by the Federal Institute for Drugs and Medicinal Devices/BfArM, Germany 08.03.2013.12. Schuster G. M., Schwarz M. P. Flupirtine: a review of its neuroprotective and behavioral properties // CNS Dmg Review. 1998. Vol. 4. P. 149—164.13. Tulle T. N., Freynhagen R. J., Versavel M. P. et al. Flupertine for relief of neuropatic pain associated with diabetic neuropathy: A randomized, double-blind study // Eur. J. Pain. 2007. Vol. 16. P. 563—566.14. Wörz R. N. Long-term treatment with flupirtine. 7 years continuous therapy of a chronic pain syndrome // Schmerz. 2000. Vol. 14. P. 29—32.V.YurchenkoL.NyzhnikM.AbzhalovI.VaysbeynG.KuznetsovL.SavichThe article describes endosurgical treatment of obstructive jaundice caused by large and multiple calculi of the bile ducts. The authors analyse reasons for a decreasing efficiency of the method and offer a more advanced operating technique. The article contains a comparative study of the proposed technique and the traditional endosurgery and open surgery methods.06022026111. Александров С. В. Возможности эндоскопической лазерной литотрипсии у пациентов с холангиолитиазом // Новости хирургии. 2013. Т. 21, № 2. C. 45—53.2. Клименко Г. А. Холедохолитиаз, диагностика и оперативное лечение. М., 2000.3. Охотников О. И., Григорьев С. Н., Яковлева М. В. Рентгенхирургическое лечение синдрома Мириззи у больных с высокой степенью операционно-хирургического риска // Анналы хирургической гепатологии. 2009. Т. 14, № 3. С. 2225.4. Ревякин В. И., Гринёв С. В., Прокушев В. С. Тактика рентгенэндоскопических методов лечения холедохолитиаза // Эндоскопическая хирургия. 2008. № 2. С. 3—9.5. Столин А. В., Нишневич Е. В., Прудков М. И. Значение признаков системного воспалительного ответа в диагностике и лечении гнойного холангита // Анналы хирургической гепатологии. 2009. Т. 14, № 2. С. 16—21.6. Binmoeller K. F., Brückner M., Thonke F., Soehendra N. Treatment of difficult bile duct stones using mechanical, electrohydraulic and extracorporeal shock wave lithotripsy // Endoscopy. 1993. N 25. Р. 201—206.7. Freitas M. L., Bell R. L., Duffy A. J. Choledocholithiasis: evolving standards for diagnosis and management // World J. Gastroenterol. 2006. N 12. Р. 3162—3167.8. Kim H. J., Choi H. S., Park J. H. et al. Factors influencing the technical difficulty of endoscopic clearance of bile duct stones // GastrointestEndosc. 2007. N 66. Р. 1154—1160.9. Lauri A., Horton R. C., Davidson B. R. et al. Endoscopic extraction of bile duct stones: management related to stone size // Gut. 1993. N 34. Р. 1718—1721.10. Lee J. E., Moon J. H., Choi H. J. et al. Endoscopic treatment of difficult bile duct stones by using a double-lumen basket for laser lithotripsy — a case series // Endoscopy. 2010. Vol. 42. Р.169—172.11. Ramírez G. J. Factors related to therapeutic failure in the extraction of bile duct stones for endoscopic retrograde colangiopancreatography ERCP // Rev Gastroenterol Peru. 2011. Vol. 31, N 4. Р. 330—334.12. Samardzic J., Latic F., Kraljik D. et al. Treatment of common bile duct stones is the role of ERCP changed in era of minimally invasive surgery? // Med Arh. 2010.Vol. 64. Р. 187—188.13. Stain S., Cohen H., Tsuishoysha M. et al. F. Choledocholithiasis. Endoscopic sphincterotomy or common bile duct exploration // Annals of Surgery. 1991.Vol. 213, N 6. Р. 27—33.14. Strömberg C., Nilsson M. Nationwide study of the treatment of common bile duct stones in Sweden between 1965 and 2009 // Br. J. Surg. 2011. Vol. 98. Р. 1766—1774.15. Trikudanathan G., Navaneethan U., Parsi M. A. Endoscopic management of difficult common bile duct stones // World J Gastroenterol. 2013. Vol. 19, N 2. Р. 165—173.16. Üsküdar O., Parlak E., Dışıbeyaz S. et al. Major predictors for difficult common bile duct stone // Turk J. Gastroenterol. 2013. Vol. 24, N 5. Р. 423—429.Korostelyov V.†The author uses longitudinal observation to identify risk factors, pathogenesis and clinical characteristics of the senile and endogenous depression in women. It is noted that a comparison of clinical characteristics06022026111. Плотников С. М. К патогенезу, клинике и терапии инволюционного психоза. Ижевск, 1972.2. Фотьянов М. И. О затяжном течении инволюционной депрессии : дис. … канд. мед. наук, М., 1965.3. Бутырина З. В. Результаты отдаленного катамнеза депрессивных психозов инволюционного возраста // Журнал невропатологии и психиатрии им. С. С. Корсакова. 1976. № 6. С. 884—890.4. Штернберг Э. Я. Геронтологическая психиатрия. М., 1977.5. Материалы Всесоюзного симпозиума по проблеме инволюционных психозов. М., 1980.N.KazantsevaV.IzranovOver the past 30 years, ultrasound examination during pregnancy revealed a surprising variety of fetus movements. It has been proven that the fetal activity begins at the end of the embryo period, week 7—9 of gestation. The analysis of the movemental patterns of the fetus has led to the hypothesis that these patterns directly reflect the development and maturation of the central nervous system. The 2D-4D ultrasound makes it possible to identify measurable parameters for assessing the neurological and behavioural development ofthe fetus. Multicentre studies were performed to identify normal and abnormal movements of the fetus. Having analysed the obtained data, the authorspropose a set of criteria for assessing the fetus neurological behaviour, allowing clinicians to better predict neurological outcome of a high-risk pregnancy.06022026111. Vries J. I. P. de, Visser G. H. A., Prechtl H. F. R. The emergence of fetal behaviour. 1. Qualitative· aspects // Early Hum Develop. 1982. Vol. 7. P. 301—322.2. Vries J. I. P. de, Visser G. H. A., Prechtl H. F. R. The emergence of fetal behaviour. II. Quantitative aspects// Early Hum Develop. 1985. Vol. 12. P. 99—120.3. Prechtl H. F. R., Nolte R. Motor behaviour of preterm infants //Continuity of neural functions from prenatal to postnatal life / ed. H. F. R. Prechtl. Oxford, 1984. Vol. 94. P. 79—92.4. Einspieler C., Prechtl H. F. R., Ferrari F. et al. The qualitative assessment of general movements in preterm, term and young infants — review of the methodology // Early Human Development. 1997. Vol. 50. P. 47—60.5. Amiel-Tisson C., Gosselin J. From neonatal to fetal neurology: some clues for interpreting fetal findings // Donald School Journal of Ultrasound in Obstetrics and Gynecology. 2008. Vol. 2(3). P. 48—63.6. DiPietro J. A., Bronstein M. H., Costigan K. A. et al. What does fetal movement predict about behavior during the first two years of life? // Dev Psychobiol 2002. Vol. 40. P. 358—371.7. Kurjak A., Tikvica A., Stanojevic M. et al. The assessment of fetal neurobehavior by three-dimensional and four-dimensional ultrasound // The Journal of Maternal-Fetal and Neonatal Medicine. 2008. Vol. 21(10). P. 675—684.8. Prechtl H. F. R., Fargel J. W., Weinmann H. M., Bakker H. H. Postures, motility and respiration of low-risk preterm infants // Developmental Medicine & Child Neurology. 1979. Vol. 21. P. 3—27.9. Prechtl H. Qualitative changes of spontaneous movements in fetus and preterm infants are the marker of neurological dyssfuction // Early Human Development. 1990. Vol. 23. P. 151—159.10. Einspieler C., Prechtl H. F. R., Ferrari F. et al. The qualitative assessment of general movements in preterm, term and young infants — review of the methodology // Early Human Development. 1997. Vol. 50. P. 47—60.11. Prechtl's Method on the Qualitative Assessment of General Movements in Preterm, Term and Young Infants / Ch. Einspieler, H. F. R. Prechtl, A. F. Bos [et al.]. Cambridge, 2005.12. Hopkins B., Prechtl H. F. R. A qualitative approach to the development of movements during early infancy //Continuity of Neural Functions from Prenatal to Postnatal Life / ed. H. F. R. Prechtl. MacKeith Press, 1984. P. 17—97.13. Hadders-Algra M. General movements: a window for early identification of children at high risk for developmental disorders // J. Pediatr. 2004. Vol. 145. P. 12—18.14. Einspieler C., Marschik P. B., Prechtl H. F. R. Human Motor Behavior Prenatal Origin and Early Postnatal Development // Journal of Psychology. 2008. Vol. 216(3). P. 148—154.15. Prechtl H. F. R. Qualitative changes of spontaneous movements in fetus and preterm infants as marker of neurological dysfunction // Early human Dev. 1990. Vol. 23. P. 151—158.16. Kurjak A., Andonotopo W., Hafner T. et al. Normal standards for fetal neurobehavioral developments — longitudinal quantification by four-dimensional sonography // J. Perinat. Med. 2006. Vol. 34. P. 56—65.17. Prechtl H. F. R. General movement assessment as a method of developmental neurology: new paradigms and their consequences // Developmental Medicine & Child Neurology. 2001. Vol. 43. P. 836—842.18. Groen S. E., de Blecourt A. C., Postema K., Hadders-Algra M. General movements in early infancy predict neuromotor development at 9—12 years of age // Dev. Med. Child Neurol. 2005. Vol. 47. P. 731—736.19. Hadders-Algra M. General movements: a window for early identification of children at high risk of developmental disorders // J. Pediatr. 2004. Vol. 145. P. 12—18.20. Einspieler C., Marschik P. B., Prechtl H. F. R. Human Motor Behavior Prenatal Origin and Early Postnatal Development // Journal of Psychology 2008. Vol. 216(3). P. 148—154.21. Feller M. B. Spontaneous correlated activity in developing neural circuits // Neuron. 1999. Vol. 22. P. 653—656.22. O’Donovan M. J. The origin of spontaneous activity in developing networks of the vertebrate nervous system // Current pinion in Neurobiology. 1999. Vol. 9. P. 94—104.23. Grillner S., Deliagina T., Ekeberg O. E. et al. Neural networks that co-ordinate locomotion and body orientation in lamprey // Trends in Neurosciences. 1995. Vol. 18. P. 270—279.24. Cazalets J. R., Squalli-Houssaini Y., Clarac F. Activation of the central pattern generators for locomotion by serotonin and excitatory amino acids in neonatal rat // Journal of Physiology. 1992. Vol. 455. P. 187—204.25. Alexander G. E., Crutcher M. D. Functional architecture of basal ganglia circuits: neural substrates of parallel processing // Trends in Neurosciences. 1990.Vol. 13. P. 266—271.26. Hadders-Algra M. The Neuronal Group Selection Theory: a framework to explain variation in normal motor development // Developmental Medicine & Child Neurology. 2000. Vol. 42. P. 566—572.27. Hadders-Algra M. General movements: a window for early identification of children at high risk of developmental disorders // Journal of Pediatrics. 2004. Vol. 145. P. 12—18.28. Ferrari F., Cioni G., Prechtl H. F. R. Qualitative changes of general movements in preterm infants with brain lesions // Early Human Development. 1990. Vol. 23. P. 193—233.29. Prechtl H. F. R., Einspieler C., Cioni G. et al. An early marker for neurological deficits after perinatal brain lesions // Lancet. 1997. Vol. 349. P. 1361—1363.30. Prechtl H. F.R,. Ferrari F., Cioni G. 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P. 119—132.36. Bos A. F., Einspieler C., Prechtl H. F. R. Intrauterine growth retardation, general movements and neurodevelopmental outcome — a review // Developmental Medicine& Child Neurology. 2001. Vol. 43. P. 61—68.37. Bos A. F., Martijn A., Asperen R. M. van et al. Qualitative assessment of general movements in high risk preterm infants with chronic lung disease requiring dexamethasone therapy // Journal of Pediatrics. 1998. Vol. 132. P. 300—306.38. Bos A. F., Asperen R. M. van, Leeuw D. M. de, Prechtl H. F. R. The influence of septicaemia on spontaneous motility in preterm infants // Early Human Development. 1997. Vol. 50. P. 61—70.39. Ferrari F., Prechtl H. F. R., Cioni G. et al. Behavioural states, posture and spontaneous movements in infants affected by brain malformation // Early Human Development. 1997. Vol. 50. P. 87—113.40. Kainer F., Prechtl H. F. R., Engele H., Einspieler C. Prenatal and postnatal assessment of the quality of general movements in infants of women with type-I diabetes mellitus // Early Human Development. 1997. Vol. 50. P. 13—25.41. Iersela P. A. M. van, Bakkerb S. C. M., Jonkera A. J. H., Hadders-Algrac M. Quality of general movements in term infants with asphyxia// Early Human Development. 2009. Vol. 85 (1). P. 7—12.42. Hamer E. G., Bos A. F., Hadders-Algra M. Specific characteristics of abnormal general movements are associated with functional outcome at school age// Early Human Development. 2016. Vol. 95. P. 9—13.A.ErmakovThe author analyses the problem of suicide. The article contains a statistical analysis of 349 cases of suicide committed by the inhabitants of the city of Kaliningrad in 2013—2015. The author examines the age and sex of the victims, seasonal characteristics of suicides, their distribution by day of the week and day of the month, the scene of suicides, alcohol intoxication and its degree.06022026111. Иванова А. Е., Сабгайда Т. П., Семенова В. Г. и др. Смертность российских подростков от самоубийств. М., 2011.2. Богоявленский Д. Впереди планеты всей // Демоскоп Weekly. 2001. № 5.3. Валиахметов Р. М., Мухамадиева Р. Р., Хилажева Г. Ф. Печальное лидерство России // Демоскоп Weekly. 2012. № 523—524.4. Морев М. В., Любов Е. Б. Социально-экономический ущерб вследствие смертности населения от самоубийств // Экономические и социальные перемены: факты, тенденции, прогноз. 2011. Т. 6 (18). С. 119—130.V.SeledtsovA.GoncharovV.ShmarovV.MalashchenkoM.MeniailoN.GazatovaN.TodosenkoA.MelnikovO.MelaschenkoA.MarkhaychukE.ShvecovaThe authors present the results of a study proving a direct effect of GM-CSF and Epo on the functional activity and activation status of T-cells in varying degrees of differentiation. The obtained data demonstrate immunoregulatory and anti-inflammatory properties of Epo and CSF-GM. 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