2014 Issue №1

The leading mechanisms and causes of severe therapy resistant asthma are poorly understood. The aim of this study was to define global patterns of gene expression in adults with severe therapy-resistant asthma. Performed 24-week prospective interventional study in parallel groups. Severe asthma patients was aposterior divided at therapy sensitive and resistant patients according to ATS criteria. Global transcriptome profile was characterized using the Affymetrix HuGene ST1.0 chip.

This article focuses on the current state of research on the properties of skin chronoaging. The authors analyse the possibility of practical application of the existing diagnostic methods of assessing age-related skin transformations for establishing the age of living persons in the framework of forensic identification tests. Major trends in the development of the methodology of age estimation from skin and its appendages are described.