Case study: treatment of a patient with Т- cell lymphoma (delta-gamma-variant)
In this article, we present a clinical case of a patient with T-cell lymphoma (delta-gamma variant) complicated by neuroleukemia. We performed a differential diagnosis from other lymphoproliferative diseases. Our diagnosis was based on trepanobiopsy and immunophenotyping data: delta-gamma-T/NK-cell lymphoma, hepatolienal form. The first NHL-BFM 90 protocol block was obtained. We performed a whole body PET/CT scan and a myelogram to confirm the diagnosis. Since therapy was ineffective, we conducted...
Dialektik als Logik des Scheins. Zu Kants Lektüre von Michael Piccarts Isagoge
An unrecognised copy (1665) in Kant’s private library of Michael Piccart’s Isagoge (1605), an introduction to the system of Aristotelian philosophy together with Kant’s own remarks on this author (Refl 4160, AA 17, p. 439) can be established as an original source for the Kantian ‘ideosphere’. First, I point out contexts and consequences of Piccart’s Altdorfian Aristotelianism, in contrast to the Königsbergian Aristotelianism (emphasised by Tonelli’s research). To further check the...
Ideas of Kant’s theoretical philosophy in Peirce’s graph theory
C. S. Peirce is a prominent figure in the nineteenth-century American philosophy. His contribution to philosophy and logic is enormous. The significance of some of his ideas was not realized until today. As a philosopher, Peirce was shaped by Kant, whose Critique of Pure Reason he knew almost by heart. Peirce was fascinated by the German thinker, who literally opened for him the philosophy of modern era and introduced him to the problem of cognition and increment of knowledge. Peirce was never a...
The genetic patterns of severe therapeutically resistant asthma as shown by a transcriptomic study: An analysis of gene ontology and KEGG pathways
The leading mechanisms and causes of severe therapy resistant asthma are poorly understood. The aim of this study was to define global patterns of gene expression in adults with severe therapy-resistant asthma. Performed 24-week prospective interventional study in parallel groups. Severe asthma patients was aposterior divided at therapy sensitive and resistant patients according to ATS criteria. Global transcriptome profile was characterized using the Affymetrix HuGene ST1.0 chip.
1. Global Burden...